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Abstracts and Publications

Abstracts and Publications

Aulos ASCO Poster 2024
Updated results of a phase 1/2 study of AU-007, a monoclonal antibody (mAb) that binds to IL-2 and inhibits CD25 binding, in patients with advanced solid tumors

Rasco D, McKean M, Haydon A, et al.

Poster presentation at the American Society of Clinical Oncology (ASCO), June 2024

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A phase 1/2 study of AU-007, a monoclonal antibody (mAb) that binds to IL-2 and inhibits CD25 binding, in patients with advanced solid tumors: Interim results from dose escalation (NCT05267626)

Frentzas S, Ahern E, Weickhardt A, et al.

Poster presentation at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 2023

Poster presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, October 2023
Preliminary pharmacodynamic evaluation of AU-007 in a phase 1a dose escalation trial for solid tumors (NCT05267626)

Vasselli J, Ahern E, Frentzas S, et al.

Poster presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, October 2023

Journal of Cancer Immunology article Thumbnail
Negative Feedback Expansion of Tregs Caused by Endogenous IL-2 Limits the Activity of IL-2-based Therapies

Amit I, Levitin N, Gadrich M, et al.

Peer-reviewed article in Journal of Cancer Immunology, J Cancer Immunol. 2023;5(1):29-39

Initial Data From Phase 12 Clinical Trial of AU-007 Show Trend in Decreasing Tregs
Initial results from dose escalation of a phase 1/2, first-in-human, open label study of AU-007, a monoclonal antibody that binds to IL-2 and prevents its binding to CD25, in patients with solid tumors

Vasselli J, De Souza P, Frentzas S, et al.

Poster presentation at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 2022

AULOS SITC 2021 AU-007 Preclinical Data Poster FINAL
AU-007, a computationally designed human antibody, mediates human immune activation by endogenous IL-2, while uniquely breaking the IL-2 negative feedback loop and preventing Treg expansion

Amit I, Levin I, Wyant T, et al.

Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 2021

Computationally Designed Antibodies Unlocking the Body’s Own IL-2 to Fight Cancer

Yanay Ofran, Ph.D.

Poster presentation video at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 2021

AU-007

AU-007’s unique mechanism of action achieves what no other IL-2 therapeutic in development does – tips the balance toward immune activation and away from immune suppression.

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